TP53 and neoplasm: Mechanistically, it has been suggested that the RNA chaperone activity of La supports, on one hand, the processing of non-coding RNAs and, on the other hand, the translation of selective mRNAs characterized by a highly structured 5′-untranslated region and often encoding tumor-promoting factors, such as cell cycle regulator cyclin D1 [65], tumor suppressor p53 regulator MDM2 [66] and anti-apoptotic factor Bcl2 [67].