BAP1 and cancer: Second primary cancers (SPCs) or multiple cancers have been proposed as possible markers of genetic or familial clustering [9]; indeed, in a study of next-generation sequencing of 85 cancer susceptibility genes on germline DNA from 198 patients with pleural, peritoneal, and tunica vaginalis mesotheliomas, having a diagnosis of SPC significantly increased the odds of carrying a BAP1 germline mutation [5].