In addition to the direct lysis of target cells, the secretion of IFNγ by activated NK cells enhances antiviral, antibacterial, and anti-tumor activity through a variety of mechanisms, including the promotion of macrophage activation, improved dendritic cell antigen presentation, and enhanced lymphocyte endothelium interactions, as well as the regulation of cellular proliferation and apoptosis [9,10,11,12,13,14]. This evidence concerns the gene IFNG and neoplasm.