In two CRC cell lines (HCT116 and SW480) with plasmid-driven HMGA2 overexpression, γH2AX foci were present at several time points following the irradiation of cells [119], which is consistent with HMGA2 inhibiting non-homologous end joining (NHEJ) and DSB repair. This evidence concerns the gene HMGA2 and colorectal carcinoma.