HMGA2 and colorectal carcinoma: Indeed, previous studies show increased HMGA2 expression may promote CRC metastasis by enhancing P53 ubiquitination and its subsequent degradation through the E3 ubiquitin ligase MDM2, transcription regulation of FN1 and IL11 (i.e., IL11/STAT3 pathway) [125] and activation of the WNT/ß-catenin pathway [126].