PiHL reduces (Enhancer of Zeste Homolog 2) EZH2-mediated tri-methylation of histone H3 at lysine 27 (H3K27me3) at the HMGA2 promoter to de-repress HMGA2 expression in CRC (Table 2) [137]. The gene discussed is HMGA2; the disease is colorectal carcinoma.