Indeed, previous studies show increased HMGA2 expression may promote CRC metastasis by enhancing P53 ubiquitination and its subsequent degradation through the E3 ubiquitin ligase MDM2, transcription regulation of FN1 and IL11 (i.e., IL11/STAT3 pathway) [125] and activation of the WNT/ß-catenin pathway [126]. The gene discussed is TP53; the disease is colorectal carcinoma.