Moreover, they determined that HMGA2 co-localized with the replication fork proteins, Proliferating Cell Nuclear Antigen (PCNA) and Replication Protein A (RPA), at sites of ongoing and arrested DNA replication forks, which was associated with reduced DSBs following hydroxyurea (HU)-induced replication fork stalling in both mouse embryonic fibroblasts and human cancer cells. The gene discussed is HMGA2; the disease is cancer.