HMGA2 and colorectal carcinoma: In addition to signaling pathways, non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circularRNAs (circRNAs), have been identified as either targets or promoters of HMGA2 expression in a CRC specific context (Table 2), in which aberrant activity frequently correlates with more aggressive CRCs (i.e., metastasis and therapeutic resistance).