The number of CD4+ T cells in the TN was significantly lower for E-NECs than for ESCC (185/mm2 vs. 567/mm2, p = 0.007), and the difference was more prominent between pNECs and ESCC (110/mm2 vs. 567/mm2, p = 0.021; Figure 7A). Here, CD4 is linked to esophageal squamous cell carcinoma.