CD4 and esophageal squamous cell carcinoma: In the TS, the number of CD8+ T cells was not significantly different between E-NECs and ESCC (887/mm2 vs. 1143/mm2, p = 0.125); however, the number of CD4+ T cells was lower for E-NECs than for ESCC (1545/mm2 vs. 2872/mm2, p = 0.013).