In contrast, high expression of REV7 is associated with favorable prognosis in colon cancer patients, and REV7 overexpression suppresses cell proliferation, migration, and clonogenicity in colorectal cancer cells via the degradation of nuclear receptor coactivator 3 (NCOA3), a transcriptional coactivator that interacts with REV7 [100]. Here, MAD2L2 is linked to colorectal cancer.