Inactivation of REV7 with siRNA-mediated knockdown or CRISPR/Cas9 system-mediated gene silencing in a variety of cancer cells promotes the inhibition of cell growth, mobility, invasion, clonogenicity, and EMT in vitro, indicating that REV7 expression affects the nature of cancer cells [87,89,90,91,92,93,94,95,96,99]. This evidence concerns the gene MAD2L2 and cancer.