MAD2L2 and central nervous system cancer: Although REV7 expression is low in most normal human tissues except for the testis, its expression is relatively high in various human tumor tissues, including colon, ovarian, breast, esophageal, lung, and skin cancers, gliomas, diffuse large B cell lymphomas, and testicular germ cell tumors (TGCTs) [85,86,87,88,89,90,91,92,93].