S. cerevisiae rev7 mutants showed a deficiency in UV-induced reversion mutations [1,2], while depletion in REV7 by RNA interference in human fibroblasts or nasopharyngeal carcinoma cells decreases UV-induced or chemotherapy-induced mutation frequencies of HPRT, respectively [60,61], indicating that REV7 is involved in DNA damage-induced mutagenesis. The gene discussed is MAD2L2; the disease is nasopharyngeal carcinoma.