MAD2L2 and nasopharyngeal carcinoma: Hypersensitivity to DNA-damaging agents such as cisplatin, carboplatin, melphalan, chlorethamine, doxorubicin, mitomycin c, or γ-irradiation, but not to H2O2, 5FU, taxol, or vincristine, decreased spontaneous and damage-induced mutation frequency, accumulation of DSBs and increased chromosomal aberrations after DNA damage, and suppressed cisplatin-induced SCE are promoted by REV7 depletion in nasopharyngeal carcinoma cells [61].