The small molecules ZINC97017995 and ZINC25496030, identified in a screen for molecules interfering with the interaction between REV1 and the REV7 dimer, directly bind to the REV7 dimer and disrupt REV7–REV1 interactions in vitro, enhancing the cell death effect of cisplatin in lung cancer cell lines [108]. The gene discussed is REV1; the disease is lung cancer.