Previous studies have proposed that ROS is associated with the development of a variety of tumors [15,22], and SOS based on the biomarkers of systematic oxidative stress in peripheral blood, including CRE, TBIL, LDH, BUN, and ALB, have yielded adverse results in the prognostication of breast cancer [23], but their role in the prognosis of patients with early-stage NSCLC is unclear. This evidence concerns the gene ALB and breast carcinoma.