MATN3 and osteoarthritis: MiR-483 is known to target tissue inhibitors of metalloproteinases 2 (TIMP2), and a recent study suggests that inhibition of miR-483-5p by intra-articular injection of antago-miR-483-5p could prevent the onset of osteoarthritis (OA) pathogenesis by targeting Matrilin 3 (Matn3) and TIMP2 [75].