EDN1 and idiopathic pulmonary arterial hypertension: A recent report suggests that under-expression of miR-483 in serum from patients with idiopathic pulmonary arterial hypertension (IPAH) revealed that miR-483 targets several PAH-related genes, including transforming growth factor-β (TGF-β), TGF-β receptor 2 (TGFBR2), β-catenin, connective tissue growth factor (CTGF), interleukin-1β (IL-1β), and endothelin-1 (ET-1) and overexpression of miR-483 in endothelial cells (ECs) inhibited inflammatory and fibrogenic responses [51].