GRN and neoplasm: The activated and progranulin-expressing Sca−/cKit−/CD45+ bone marrow-derived cells were then recruited to the site of the indolent tumor HMLER-HR, which was injected on the other flank, where they released progranulin, thereby stimulating expression and production of chemokines, cytokines, growth factors and matrix remodeling proteases by stromal fibroblasts and myofibroblasts, favoring growth and progression of these indolent tumors [104].