Invasive breast cancer that expresses the two hormone receptors (HRs), estrogen receptor (ER), and progesterone receptor (PR) and presents a negative HER2 status and low expression level of the proliferation marker Ki-67 (+/− low or intermediate tumor grade) is classified as luminal A-like tumors; HR-positive, HER2-negative breast cancer with a high Ki-67 level +/− high tumor grade (G3) is classified as the luminal B-like subtype. Here, ESR1 is linked to neoplasm.