For EAs, the SNP pairs rs1801133- rs2236225 in MTHFR and MTHFD1 (p = 0.009, 68.8% significance) and rs1801131- rs7587117 in MTHFR and SLC4A5 (p = 0.018, 69% significance) were significantly associated with PCa aggressiveness (Table 4). This evidence concerns the gene MTHFD1 and posterior cortical atrophy.