In turn, TIM-3 possesses four potential ligands that can interact with the IgV domain of TIM-3; these are galectin-9 (Gal-9), a nuclear and plasma glycoprotein involved in signal transduction processes and numerous aspects of tumour progression [6]; HMGB1, a molecule released by necrotic/suffering cells, the prototype of Damage Associate Molecular Patterns (DAMPs) [7]; the carcinoembryonic antigen cell adhesion molecule or Ceacam-1, predominantly expressed by activated T lymphocytes [8] and, finally, phosphatidylserine (PtdSer) expressed on the apoptotic cells membranes [8]. This evidence concerns the gene HMGB1 and neoplasm.