HIF1A and colorectal cancer: AM expression has been associated with vascular endothelial growth factor (VEGF) and HIF-1α in colorectal cancer; these molecules are involved in angiogenesis, and the authors of the study suggested that the degree of AM expression could be used as a marker for the prediction of cancer-related death and high risk of relapse in colorectal cancer patients with a curative resection [203].