RAB27B and cancer: Similarly, based on TCGA data analysis, Hua et al. have shown that RAB27B is possibly implicated in rectal adenocarcinoma metastasis [26], while Cheng et al. have shown that RAB27B plays a significant role in the secretion of CRC stem cell sEVs, which seem to promote cancer initiation forming an immunosuppressive tumor microenvironment [27].