In this context, we assessed the clinical value of 8 genes (RAB2B, RAB3B, RAB9A, RAB11B, RAB27A, RAB27B, STX1A, and VAMP7), which are implicated in sEVs biogenesis, as well as their association with overall and tumor-derived plasma sEVs levels. This evidence concerns the gene RAB27B and neoplasm.