The present study has significant limitations including the missing H3K27M mutational status for 11 of the 41 DIPG patients, and the bioinformatics-based analyses used without additional supportive laboratory testing of TGFB2 mRNA levels and mRNA levels of correlated transcription factors using other assay platforms such as quantitative RT-PCR and validated immunohistochemistry tests that are not available. Here, TGFB2 is linked to diffuse intrinsic pontine glioma.