TGFB3 expression has also been detected in human glioma cells and depletion of TGFB3 mRNA using TGFB3-specific antisense oligonucleotides decreased the invasiveness of human glioma cells in vitro, but its role in pathobiology or prognosis of high-grade gliomas remains unknown [60]. This evidence concerns the gene TGFB3 and central nervous system cancer.