IN VITRO- inhibition of cell proliferation in a dose-dependent manner in all cell lines- induction of arrested cell cycle progression in the G2/M phase- inhibition of expression of proteins involved in the RAS/RAF/ERK and PI3K/AKT/mTOR signaling pathways- induction of apoptosisIN VIVOsuppression of tumor growth in mice. This evidence concerns the gene PIK3CA and neoplasm.