ImmunohistochemistryIncrease in levels of SGLT2 in thyroid cancer in comparison with adjacent tissueIn VITRO- inhibition of glucose uptake and glycolysis levels- inhibition of AKT/mTOR activation- induced AMPK activation- Increased apoptosis due to G1/S phase transition arrestIN VIVO:Suppression of tumor growth in mice. The gene discussed is AKT1; the disease is thyroid gland carcinoma.