MTOR and neoplasm: ImmunohistochemistrymTORC1 expression in 81% samples;mTORC2 expression in 39% co-expression32.5%IN VITRO- prevention of mTORC1 and mTORC2 activity- inhibition of mTOR activity leading todownregulation of cyclin D1- induction of mitochondrial-mediatedapoptosisIN VIVO- decrease in tumor volume and size in mice