TP53 and neoplasm: Activated TP53 then interacts with other tumor suppressors such as p21Waf1/Cip1, p63, and p73, activates numerous microRNAs (including the miR-34 family of miRNAs) and proapoptotic proteins (BCL-XL, BCL2, Bax), and alters the function of mTOR kinase.