Interestingly, many tumors from sub-cluster B2a (41 out of 63) and HPV16-positive HNSCC (35 out of 59) were classified as UCHL1-related, further supporting elevated UCHL1 function, despite moderate expression values, in a substantial amount of HPV16-positive OPSCC (Supplementary Figure S3B,C). The gene discussed is UCHL1; the disease is head and neck squamous cell carcinoma.