By multivariate analysis, AFP at the value of <28 ng/mL evaluated at HCC diagnosis, was the only factor associated with a better prognosis (adjusted hazard ratio, aHR = 0.271, 95% confidence interval, CI = 0.078–0.948, p = 0.041), after adjusting for male sex, CD8 cell count, and total lymphocytes. The gene discussed is CD8A; the disease is hepatocellular carcinoma.