Current guidelines for screening of adults with germline CHEK2 alterations include the consideration of annual breast MRI beginning at age 35–40, annual mammograms beginning at age 40 or 5–10 years before the earliest breast cancer diagnosis in the family, and colonoscopy every 5 years beginning at age 40 or 5–10 years before the earliest colon cancer diagnosis in the family [67,68]. This evidence concerns the gene CHEK2 and breast cancer.