Somatic analysis of the disease-involved sample was consistent with non-WNT/non-SHH medulloblastoma, including ZMYM3 p.Ala217fs and SETD2 p.Glu1582Lys variants, in addition to copy number gain of chromosome 7, loss of chromosome 8 and 13, and isochromosome 17q. The gene discussed is SETD2; the disease is medulloblastoma.