A large panel sequencing study of somatic mutations in RMS tumor samples, which identified 17 MYOD1L122R cases, illustrates the enrichment of other mutations found in mutant MYOD1 cohorts, particularly PIK3CA and other PI3K pathway genes which are involved in approximately half of mutant MYOD1 tumors, and the RAS pathway which accounts for at least another quarter [18]. The gene discussed is MYOD1; the disease is neoplasm.