This phenomenon intensifies the accompanying characteristic changes of components, such as citrullinated histone H3 and myeloperoxidase (MPO), which stimulate the immune cells to secrete TNF-α and induct changes in both stroma and epithelial cells, via oral malignant transformation and tumour matrix degradation downstream of TNFα/TNFR1 [187,205]. This evidence concerns the gene MPO and neoplasm.