A similar functional effect in tumour development occurs as a result of overexpression of the endothelin B receptor (ETB), which stimulates upregulation of the ICAM-1 molecule on endothelial cells, leading to reduced efficiency of the trafficking of T cells to the tumour and enhanced apoptosis, as well as more intense proliferation, migration and invasiveness of tumour cell lines [356,357,358,359]. Here, ICAM1 is linked to neoplasm.