Interestingly, HPV-positive tumours demonstrate stronger activation of several immune signalling pathways, as well as the higher expression of genes related to total tumour-infiltrating lymphocytes (TILs), CD8+ T cells, effector cytotoxic cells (CTLs), exhausted CD8+ cells and macrophages (TAMs) than HPV-negative types. This evidence concerns the gene CD8A and neoplasm.