Interestingly, several studies have also investigated the influence of CD4+ subset of TILs on prognosis in HPV+ patients; however, they have yielded contradictory results for both OS (HR 1.33; 95% CI: 0.63–2.81) and LRC (HR 1.56; 95% CI: 0.78–3.12) in the studied HNSCC group [65,73]. This evidence concerns the gene CD4 and head and neck squamous cell carcinoma.