It has been proposed that a combination of inhibitors of signal transducer and activator of transcription 3 (STAT3) with radiation may improve tumour growth delay and reduce Tregs activity, and increase myeloid-derived suppressor cell (MDSC) stimulation, M2 macrophages and enhanced effector T cells and M1 macrophages [126]. The gene discussed is STAT3; the disease is neoplasm.