For example, the use of nanocomplex-based on gold nanoparticles (AuNPs) conjugated with anti-EGFR cetuximab by the immobilization of cetuximab on the AuNPs surfaces, demonstrated long-term stability, EGFR affinity and cancer cell death due to apoptosis of several cancer cells, including HNSCCs. The gene discussed is EGFR; the disease is cancer.