It was also shown that aberrant PD-L1 expression on the CD133+CD44+ CSC cell population was associated with increased activation of the Notch3/mTOR signalling axis and HMGA1-dependent pathways, including PI3K/AKT and MEK/ERK pathways in cancer cells in vitro and in vivo [75,76]. The gene discussed is AKT1; the disease is cancer.