CCR2 and cancer: For example, clinical trials using targeted therapy with CCL2/CCR2 axis inhibitors, molecules correlated with high infiltration of TAMs in cancer biopsies, such as anti-CCL2 carlumab and anti-CCR2 PF04136309 used in combination with chemotherapy (FOLFIRINOX) (NCT01413022) have shown promising results in solid tumours [473,474].