Additionally, several blood-based markers, such as alpha-feto protein (AFP), Des-γ-carboxyprothrombin (DCP), osteopontin (OPN), glypican-3, thioredoxin reductase, circulating microRNAs, α-L-fucosidase (AFU), and CA19-9, which have been characterized for early detection of hepatocellular carcinoma (HCC), have been thoroughly reviewed previously [259,260,261,262,263]. Here, SPP1 is linked to hepatocellular carcinoma.