Interestingly, MUC5AC was found to be expressed in early precursor lesions (PanIN1A/B) and the expression persisted with the disease progression, as analyzed in the samples from benign controls (BCs), resectable early-stage PC (EPC) patients, and unresectable late-stage PC (LPC) patients [122]. This evidence concerns the gene MUC5AC and pachyonychia congenita.