This compound was the first to show the benefit of KRAS G12C inhibitor treatment on disease progression in patients, demonstrating a 37.1% response rate, a progression-free survival of 6.8 months, and a median overall survival of 12.5 months in a Phase II clinical trial of 126 patients with advanced NSCLC CodeBreaK100 (Phase II) [53]. This evidence concerns the gene KRAS and non-small cell lung carcinoma.