Differences in gene effects between amplified versus non-amplified cell lines in distinct tumor types were similar, as it was observed in SLC26A10, TSPAN31, CALM1, FKBP9, ERBB2, or CCNE1, suggesting that the biological consequences derived from the knockout of these prioritized genes are, in general, lineage-independent. The gene discussed is ERBB2; the disease is neoplasm.