As depicted in Figure 1A, miR-155-5p significantly targets 12 genes in the melanoma KEGG pathway [hsa05218] (p = 6.1 × 10−34), namely (1) CDK4, (2) EGFR, (3) CDKN2A, (4) MITF, (5) CCND1, (6) E2F3, (7) PIK3R1, (8) FGF9, (9) AKT3, (10) CDKN1, (11) FGF7, and (12) MDM2 (Supplementary Table S2). This evidence concerns the gene CDK4 and melanoma.