PIK3R1 and melanoma: As depicted in Figure 1A, miR-155-5p significantly targets 12 genes in the melanoma KEGG pathway [hsa05218] (p = 6.1 × 10−34), namely (1) CDK4, (2) EGFR, (3) CDKN2A, (4) MITF, (5) CCND1, (6) E2F3, (7) PIK3R1, (8) FGF9, (9) AKT3, (10) CDKN1, (11) FGF7, and (12) MDM2 (Supplementary Table S2).