TIMP2 and acute kidney injury: Breglia et al. [61] also reported the occurrence of CI-AKI and subclinical CI-AKI after intra-arterial administration of contrast material in patients with GFR > 60 mL/min, but they applied a combination of structural biomarkers urinary NGAL, IGFBP7 (insulin-like growth factor-binding protein 7), and TIMP-2 (tissue inhibitor of metalloproteinase-2), measured 4–8 h post-procedure.