We revealed that the expression of ITGB2, VEGFA, CLDN4, OCLN, and SPP1 were increased in serous ovarian cancer tissues compared with non-ovarian tumor ovarian tissues, and that the upregulation of these genes was associated with immune infiltration and a poor clinical outcome in serous ovarian cancer patients. This evidence concerns the gene CLDN4 and ovarian serous adenocarcinoma.