ITGB2 plays a vital role in in various disorders covering nasopharyngeal carcinoma, NSCLC (non-small cell lung cancer), glioma, breast cancer, and osteosarcoma, and non-tumor diseases, including the SSc (systemic sclerosis) and NEC (necrotizing enterocolitis) of infants [31]. This evidence concerns the gene ITGB2 and osteosarcoma.