The evidence that SHP2 has been discovered to localize not only in the plasma membrane but also within the mitochondrial intermembrane space acting as a nutrient sensor, metabolic regulator, and integral component of oxidative phosphorylation and autophagic machinery is of particular interest [18,19,29,30]; yet, its role in regulating cellular phenotypes through autophagy and metabolic reprogramming in the context of lung fibrosis is largely unknown. Here, PTPN11 is linked to pulmonary fibrosis.