Additionally, in ADPKD, there are proteins needed to remodel the matrix, such as inter-alpha-trypsin inhibitor heavy chain 5 (ITIH5), and control the secreted salt, including [guanylate cyclase activator 2B (GUCA2B) or myelin and lymphocyte (MAL)]. This evidence concerns the gene GUCA2B and autosomal dominant polycystic kidney disease.