This study marked Rho GDP-dissociation inhibitor 1 and 2, calnexin, and chloride intracellular channel protein 1 as downregulated proteins in FD patients, whereas galectin-1, 14-3-3 protein zeta/delta, 14-3-3 protein theta, and g-enolase appeared to be upregulated in FD patients [67]. The gene discussed is YWHAZ; the disease is Fabry disease.