MMP2 and cyst: Nine proteases were discovered as a result of in silico investigations of putative proteolytic pathways entangled in the production of the predicting peptides, including cathepsins D, E, and L, meprin A, matrix metallopeptidase 2 (MMP2), 3, 8, and 9, and pepsin A. Due to their involvement in the ECM turnover that occurs during cyst growth, MMPs may play a role in ADPKD.