The observation that most (546/626 [87.2%]) recovery samples (NS1 ELISA- and RT-PCR-negative, IgM ELISA-negative, and IgG ELISA-positive) and most (160/175 [91.4%]) naïve samples (negative for RT-PCR and all three dengue ELISAs) according to our algorithm, were documented with an early time from symptom onset (0–8 days; Table S1), indicate that these patients suffer from a febrile illness other than DENV. Here, CD40LG is linked to dengue disease.