There is a consensus among all guidelines that serum tumour markers, especially β-human chorionic gonadotropin (β-hCG), alpha-fetoprotein (AFP), lactate dehydrogenase (LDH) and cancer antigen 125 (CA125), should be measured in all ovarian masses with suspicious features (ESGO-SIOPE 2020, ESMO 2018, BritSPAG 2018, Centres Experts TRMG 2022, EXPeRT/PARTNER 2021) [9,24,25,26,27,35]. The gene discussed is AFP; the disease is neoplasm.