Moreover, the lower levels of ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3; underexpressed DEP with −9.95 FC), an ATPase that transports Ca2+ across membranes to the endoplasmatic reticulum to maintain a low cytoplasmic Ca2+ level in neurons of substantia nigra pars compacta in Parkinson’s disease, indicates a deficit in organelle function and Ca2+ sequestration [92]. This evidence concerns the gene ATP2A3 and Parkinson disease.