When biomarker concentrations were normalized for urine dilution, the AUC-ROC of CHI3L1, NGAL, TIMP-2, IGFBP7, and NephroCheck® was significant for predicting AKI ≥ 1 within 48 h after ICU admission (Table 4a and Figure 3). This evidence concerns the gene IGFBP7 and acute kidney injury.