KDR and cancer: (3) Results: The analysis showed improvement of pooled-PFS (HR, 0.71; 95% CI, 0.64–0.78; I2 = 77%; p < 0.00001) in first-line (HR, 0.85; 95% CI, 0.78–0.93; p = 0.0003) or recurrent cancer (HR, 0.62; 95% CI, 0.56–0.70; p < 0.00001) and regardless of the type of anti-angiogenesis drug used (Vascular endothelial growth factor (VEGF) inhibitors, VEGF-receptors (VEGF-R) inhibitors or angiopoietin inhibitors).