The study herein suggests a high TMB, with a possible genetic signature represented by the top 10 mutated genes across the four glioblastoma patients with rapid progression: MUC3A, MUC4, MUC6, OR4C5, PDE4DIP, AHNAK2, OR4C3, ZNF806, TTN, and RP1L1. Here, RP1L1 is linked to glioblastoma.