Therefore, 18F-FDG PET/CT imaging, which is broadly applied in the diagnosis, staging, follow-up and recurrence monitoring of malignant tumors, may be an alternative non-invasive strategy for predicting PD-L1 expression within a tumor; this information would be of great value for blocking PD-1/PD-L1 immunotherapy. The gene discussed is CD274; the disease is neoplasm.