AKT1 and breast carcinoma: KEGG pathway analysis also revealed that several important cancer signaling pathways were observed to be up regulated (with significant p-values, but FDR > 0.1) including PI3K-Akt, Notch, ECM–receptor interactions, regulation of actin cytoskeleton, tight junction, focal adhesion, and adherens junction signaling pathways (Figure 2(D-2), lower left panel and Supplementary Table S2B), which have been previously observed in breast cancer studies with disruption of the CmPn network [16,17,23].