KEGG pathway analysis of CCA tumor tissues revealed several up-regulated pathways (with significant p-values, but FDR > 0.1) important in cancer signaling including Wnt, AMPK, PI3K-Akt, breast cancer, prostate cancer, ECM–receptor interactions, and proteoglycans in cancer signaling pathways (Figure 2(E-2), left bottom panel and Supplementary Table S2C). This evidence concerns the gene PIK3CG and Familial prostate cancer.