Down-regulated DEGs mainly affected cholesterol/sterol/lipid homeostasis and transporting processes, hydrolase/transferase activity, cholesterol metabolism, regulation of blood coagulation, several cancer signaling cascades including complement and coagulation cascades, PPAR pathway, bile secretion, peroxisomes, and ABC transporters, as well as metabolic signaling pathways including fat digestion/absorption (Figure 2(D-2), right panels and Supplementary Table S2B). The gene discussed is PPARA; the disease is cancer.