AKT1 and cancer: Functional enrichment results obtained from significantly altered genes in CCA clinical samples demonstrated perturbation to key cancer signaling pathways including cell population proliferation/differentiation, cell junction assembly, Wnt signaling, PI3K-Akt, and Notch signaling (Figure 2(D-2)), which were also observed to be dysregulated in all of our breast cancer studies [16,17,23,27,28].