Interestingly, when we repeated our analysis to compare CCAs with HCCs, we noticed opposite regulation between the two common liver cancer subtypes including down regulation of cholesterol/triglyceride/lipid homeostasis, cholesterol transport, PPAR signaling, bile secretion, as well as ABC transporters in CCAs compared to HCCs (Figure 2(E-2)). This evidence concerns the gene PPARA and liver cancer.