Utilizing RNA-seq and IF approaches, we observed that CCM1 and nPRs were seen to be down regulated, at both the transcriptional and translational levels, in HCC and CCA tissues when compared to normal tissues, indicating that these CmPn members could be useful diagnostic biomarkers, but did not support its potential use as prognostic biomarkers in differentiating between cancer subtypes. This evidence concerns the gene KRIT1 and cancer.