After analyzing DEGs between 110 normal healthy liver tissues and 369 HCC primary tumor tissues (Supplementary Table S2A), we observed down regulation of CCM1/2, PAQR6, and nPRs in HCC primary tumor tissues, while all other CmPn players were up regulated, along with AFP (Figure 2(C-1)). This evidence concerns the gene PAQR6 and neoplasm.