Furthermore, in animal models, tumor necrosis factor-α (TNF-α) is a multifunctional cytokine expressed in adipose tissue capable of influencing insulin-induced signaling and preventing glucose transporter type 4 (GLUT-4) expression, which gives rise to higher levels of free fatty acids (FFA), and worsening insulin resistance [15]. The gene discussed is SLC2A4; the disease is Insulin resistance.