In addition, a study of iPSCs-MNs and TDP-43 mutant mice determined that cycloguanylic acid (GMP)–AMP synthase (cGAS), a cytoplasmic DNA sensor, caused upregulation of the cytokine profile of neuritis when TDP-43 entered the mitochondria and released DNA through the permeability transition pore [66]. The gene discussed is TARDBP; the disease is neuritis.