Recently, it was revealed that in sporadic ALS iPSCs, factors that affect the accumulation of nuclear RNA polymerase II (RNAP II) transcripts regulate the nucleocytoplasmic balance of FUS, and the reduction of RNAP II transcripts can cause the mislocation of FUS to the cytoplasm in ALS patients [74]. The gene discussed is FUS; the disease is amyotrophic lateral sclerosis.