BRAF and melanoma: In a retrospective cohort study investigating the genomic profiles of 29 acral, mucosal, and vulvovaginal melanomas using whole transcriptome mRNA/DNA sequencing, as well as mRNA expression profiling and UV signature analysis, alterations in BRAF were detected in 36%, compared to the mucosal and vulvovaginal melanomas showing no alterations (p = 0.0159); the study did not separate NUM from other non-NUM acral melanomas [13].