We were puzzled by this expression trend of Salmonella infection pathway genes, but we found that only six differentially expressed genes, such as AHNAK, MAP2K1, MAPK10, ARL8B, IL6, and PFN2, were enriched after S. enterica BNCC186354 infection, but only ARL8B and PFN2 were downregulated, from which we speculate that this pathway was not extensively activated after S. enterica BNCC186354, which may be related to the time and concentration of infection. This evidence concerns the gene PFN2 and infection.