In addition, our results indicated that the activity of the PI3K/AKT pathway potentially inhibits S. enterica BNCC186354 infection in IPEC-J2 cells; the PI3K/AKT pathway may be activated by L. reuteri ATCC 53,608, thereby inhibiting S. enterica BNCC186354 infection. The gene discussed is AKT1; the disease is infection.