Despite this, correlations between fibrinogen levels and different AD biomarkers were found: (1) plasma concentration of fibrinogen was positively correlated with plasma concentration of Aβ40 and Aβ42 as well as CSF concentration of T-tau and p-tau-181, but negatively correlated with CSF concentration of Aβ42; (2) plasma concentration of fibrinogen was positively correlated with T-tau/Aβ42 and p-tau/Aβ42 ratios [107] (Table 2). Here, MAPT is linked to Alzheimer disease.