In the SI rats that exhibited increased risk of breast cancer recurrence, this gene was downregulated and had lost its connection to Ndufs3, Ndufa4 (both involved in mitochondrial membrane respiratory chain), and Vdac2 (pathway for metabolite diffusion across the mitochondrial outer membrane), and gained a connection to Suclg1 (TCA cycle) and Atp6v0c (enzyme transporter that acidifies intracellular compartments in eukaryotic cells). The gene discussed is COXFA4; the disease is breast carcinoma.