Next, to assess the ability of Foldlin to affect the levels of other disease-associated aggregated proteins, we also transfected HeLa cells with wild-type superoxide dismutase 1 (SOD1), as well as the G93A and A4V SOD1 mutants, the aggregation of which occurs in a subset of familial cases of amyotrophic lateral sclerosis (ALS), where the mutant proteins form cytotoxic inclusions in the cytoplasm of motor neurons [47]. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.