Additionally, phosphorylation at Thr770, Ser854, and Ser855 within the CTD of RIG-I by casein kinase II (CK-II) was found to be necessary for maintaining the autorepressor conformation of RIG-I (Figure 2) [80], thereby preventing the improper activation of RIG-I antiviral immunity in the absence of viral infection. Here, RIGI is linked to viral infectious disease.