It is important to note that as revealed by the RNA-seq data of the TCGA HCC cohort, ARID1A mRNA is significantly upregulated in human HCC tumors as compared with the nontumorous liver samples [39], in contrast to the frequent downregulation of ARID1A protein in other ARID1A-deficient cancers. This evidence concerns the gene ARID1A and hepatocellular carcinoma.