The effects of autophagy deficiency on endMT were independent of the TGFβ pathway but IL-6-dependent: IL-6 neutralizing antibody prevented endMT in ATG5 knock-down human microvascular cells and ameliorated metabolic disorders in endothelial-selective ATG5 deficient mice fed with high fat diet [110]. The gene discussed is ATG5; the disease is Other metabolic disease.