For patients with type 2 diabetes (T2D), the most prominent type of diabetes with 90% of all diagnosed cases, several current antidiabetic drugs are from plant and animal origins: metformin, sodium glucose co-transporter type 2 inhibitors (SGLT2is) and glucagon-like peptide 1 receptor agonists (GLP-1RAs). Here, GLP1R is linked to type 2 diabetes mellitus.