TGFB1 and lactic acidosis: In line with the above-described acADSC switch toward a myofibroblastic-like phenotype under lactic acidosis, we observed that acADSCs exposed to pH 6.7 in the presence of 10 mM lactate showed a modest but significant increase in the mRNA expression of TGFB1 (i.e., gene encoding TGFβ1) compared to acADSCs grown under basal conditions (Figure 6C).