ACTA1 and lactic acidosis: On the contrary, lactic acidosis increased the expression levels of typical myofibroblast-related genes, such as ACTA2 (i.e., gene encoding α-SMA), COL1A1, and COL1A2, which were 2.5-fold, 3-fold, and 4-fold increased, respectively, compared to the basal conditions (Figure 3F–H).